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FISH (Fluorescence in situ hybridization) is a laboratory test that uses fluorescent dyes to detect specific genetic changes in chromosomes or genes. It is important for a CLL (Chronic Lymphocytic Leukemia) diagnosis because it can help identify specific genetic changes associated with the disease, such as the presence of the BCL2 gene or the deletion of the 13q14 chromosome, the 17p chromosome deletion, trisomy 12, etc. This information can help guide treatment decisions and predict the course of the disease. FISH test can also be used to distinguish between CLL and other types of leukemia or lymphoma.
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